MutaGEL® Collagen (AS) PCR Assay Kit

MutaGEL Collagen PCR Assay manufactured in Germany by Immundiagnostik

Size: 24 Samples
Method: PCR (allel specific)
Sample Type: DNA (e.g.whole blood, cheek swab)
Sample Size: 200 µL
For Research Use Only

Control Included

Storage and Stability:
Store at ≤ -18°C. The kit reagents are stable in the unopened micro tubes until the expiration date indicated (see print on the package). Do not thaw out the content of the “COL1A1 positive control DNA” for more than two times. If necessary, make suitable aliquots. Before use: Spin tubes briefly before opening (contents may become dispersed during shipment).

Assay Background

Type 1 α 1- Collagen is the major protein of bone and its structure is essential for the development of osteoporosis. In several clinical studies, an influence of the natural variation of the DNA sequence from collagenase protein was shown. The pathogen variant results in lower mineral density of bone – especially for femoral neck and lumbar spine. Therefore the osteoporotic fracture risk increases with age in patients carrying this gene variant. The investigated COL1A1- polymorphism is biallelic and changes a regulatory binding site (for the transcription factor Sp1). The more rare allele (pathogen) transfers the disease factor independent and also additional to the variability of other genetic factors involved in alteration of whole osteoporotic risk (e. g. mutations in receptors for calcitonin, vitamin D3 or estrogen). The more frequent allele has protective properties.

Products Related to MutaGEL Collagen PCR Assay

MutaGEL® Lactase PCR Assay
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