MutaGEL ACE PCR Assay Kit

MutaGEL ACE PCR Assay manufactured in Germany by Immundiagnostik

Size: 24 Samples
Method: PCR (allele-specific)
Sample Type: DNA (e.g.whole blood, cheek swab)
Sample Size: 200 µL
Alternative Names: Angiotensin-convertin Enzyme PCR Assay, Human ACE PCR Assay
For Research Use Only
Control Included

Assay Background

The angiotensin-converting enzyme (ACE) is the most important regulator of the renin/ angiotensin/ aldosterone system (RAAS). The enzyme converts angiotensin 1 into the physiologically active form angiotensin 2. Latter one unfolds its vasoconstrictive effect directly into the organs (heart, kidney, vessels). The insertion/ deletion polymorphism in the ACE gene is associated immediately at the circulating ACE level. Therefore the I / D -polymorphism influences the risk for cardiovascular complications.

In contrary, the “S”-mutation (Glu to Val in codon 246 of exon 3) has protective properties: S-homozygotes and also compound heterozygotes with the Z-mutation (SZ) does not cause liver diseases. The enzyme product of the “S”-mutation has a short half-life and consequently a decreased serum activity. Hereditary antitrypsin deficiency with organ-defects is characterized by lung emphysema or chronic hepatitis (resp. liver cirrhosis or hepatocellular carcinoma) and is in Europe with a frequency of 1: 2-5000 the main cause for the mentioned hereditary liver diseases by children.

Storage and Stability
Storage at < -18°c.="" the="" reagents="" are="" stable="" in="" the="" unopened="" micro="" tubes="" until="" the="" expiration="" date="" indicated.="" don"t="" thaw="" out="" the="" content="" of="" the="" “ace="" positive="" control="" dna”="" more="" than="" twice.="" if="" necessary,="" make="" suitable="" aliquots.="" before="" use:="" spin="" tubes="" briefly="" before="" opening="" (contents="" may="" become="" dispersed="" during="" shipment).="">

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Restrictions
The PCR results for positive control in DNA fragments of indicated length and for the samples at least one of both amplification products must be detactable. If this is not the case, the sample must be tested a second time or the complete analysis must be repeated with freshly isolated DNA. If there are no positive control DNA fragments present, the amplification was incorrect and the chosen PCR conditions have to been proven/ corrected.

EagleBio在人类中，冠状病毒会引起呼吸道感染。冠状病毒由几种蛋白质组成，包括刺突（S），包膜（E），膜（M）和核衣壳（N）。结果表明，刺突蛋白与血管紧张素转化酶2（ACE2）受体保持足够的亲和力，可将其用作细胞进入的机制。人们主要认为冠状病毒在人与人之间的传播是通过打喷嚏和咳嗽产生的呼吸道飞沫在亲密接触者之间发生的。IgG是响应抗原产生的最丰富的免疫球蛋白，在长期暴露后会保持在体内。Eagle Biosciences仅提供最优质的测定以满足您的需求，并在这些艰难的时期内为您提供最佳的客户服务。