Porphyrins HPLC Assay Column

The Porphyrins HPLC Assay Column is For Research Use Only

Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type. 

Assay Background

Hemoglobin, myoglobin and the cytochromes contain the heme structure as active site. The porphyrins are precursors of the heme molecules. They play an important role in the oxygen metabolism. The heme synthesis is located mainly in the erythrocyte cells. Glycin and succinyl-CoA are condensed to δ-aminolävulinic acid. Two molecules of δ-aminolävulinic are then condensed to porphobilinogen. The porphyrin ring is built up by four porphobilinogen molecules.

An increase of porphyrins caused by a defect in the synthesis is described as porphyria. The different porphyries are determined by the characteristic pattern of porphyrins in urine.   In autosomal dominant acute porphyrin disorders uro-, copro-, penta- und tricarboxyporphyrin are increased. In chronic porphyries including porphyria cutanea tarda the concentration of uro- and heptaporphyrin are increased. In chronic lead intoxication the coproporhyrins are slightly increased, whereas an acute lead intoxication shows extremely high excretion of porphyrins in urine.

The Eagle Biosciences Porphyrins HPLC Assay Kit makes it possible to determine them in an easy, fast and precise way. The Porphyrins HPLC Assay Kit includes all reagents in ready to use form for preparation and separation of the samples with exception of the columns (IC2601rp) and the controls (IC2601ko).   Both can be supplied by Eagle Biosciences.  Beside the complete test kit it is possible to order all components separately. Please request our single component price list.

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