Phenylalanine, Tyrosine & Tryptophan HPLC Column

The Phenylalanine, Tyrosine & Tryptophan HPLC Column is For Research Use Only

Each column is can be utilized for approximately 500-1000 samples depending on column care and sample type.

Assay Background

Phenylketonuria is the most abundant genetic disorder of the amino acid metabolism. It is characterized by a lack of phenylalanine hydroxylase which causes an increase of phenylalanine in cells and body fluids.  Due to the lack of enzyme activity, phenylalanine, normally metabolised to tyrosine, is converted to phenylpyruvic acid.  Left untreated, this can cause brain damage and progressive mental retardation. Additionally high concentrations of phenylalanine inhibit various enzymes which are involved in the synthesis of neurotransmitters and melanin. The incidence of occurrence is about 1 in 15000, varying widely in different populations.
Untreated children with phenylketonuria are normal at birth, but rather early they don´t attain early developmental milestones, show mental retardation, hyperactivity, convulsions, low pigmentation of the hair and alterations of the skin.  An early diagnosis within the first days after birth is very important. Nevertheless the blood level of phenylalanine has to be controlled regularly because reduced levels can lead to proteolysis with disturbance of growth.
The Eagle Biosciences Phenylalanine, Tyrosine & Tryptophan HPLC Assay kit makes it possible to determine phenylalanine, tyrosine and tryptophan in an easy, fast and precise method. The Phenylalanine, Tyrosine & Tryptophan HPLC Assay kit includes all reagents for preparation and separation of the samples with exception of the columns (IC4000rp) and the controls (IC4000ko). Both can be supplied by Eagle Biosciences.  Besides the complete test kits it is possible to order all components separately.  Please request our single component price list.

Related Products

Phenylalanine, Tyrosine & Tryptophan HPLC Assay
Phenylalanine, Tyrosine & Tryptophan HPLC Control Set
Homocysteine HPLC Control Set

EagleBio在人类中，冠状病毒会引起呼吸道感染。冠状病毒由几种蛋白质组成，包括刺突（S），包膜（E），膜（M）和核衣壳（N）。结果表明，刺突蛋白与血管紧张素转化酶2（ACE2）受体保持足够的亲和力，可将其用作细胞进入的机制。人们主要认为冠状病毒在人与人之间的传播是通过打喷嚏和咳嗽产生的呼吸道飞沫在亲密接触者之间发生的。IgG是响应抗原产生的最丰富的免疫球蛋白，在长期暴露后会保持在体内。Eagle Biosciences仅提供最优质的测定以满足您的需求，并在这些艰难的时期内为您提供最佳的客户服务。