Phenylalanine, Tyrosine & Tryptophan HPLC Assay

The Phenylalanine, Tyrosine & Tryptophan HPLC Assay is For Research Use Only

Size: 100 Tests
Incubation Time: 15 minutes
Sample Type: Plasma, Whole Blood, Filter Spots
Sample Size: 50 µL

Assay Background

Phenylketonuria is the most abundant genetic disorder of the amino acid metabolism. It is characterized by a lack of phenylalanine hydroxylase which causes an increase of phenylalanine in cells and body fluids.  Due to the lack of enzyme activity, phenylalanine, normally metabolised to tyrosine, is converted to phenylpyruvic acid.  Left untreated, this can cause brain damage and progressive mental retardation. Additionally high concentrations of phenylalanine inhibit various enzymes which are involved in the synthesis of neurotransmitters and melanin. The incidence of occurrence is about 1 in 15000, varying widely in different populations.
Untreated children with phenylketonuria are normal at birth, but rather early they don´t attain early developmental milestones, show mental retardation, hyperactivity, convulsions, low pigmentation of the hair and alterations of the skin.  An early diagnosis within the first days after birth is very important. Nevertheless the blood level of phenylalanine has to be controlled regularly because reduced levels can lead to proteolysis with disturbance of growth.
The Eagle Biosciences Phenylalanine, Tyrosine & Tryptophan HPLC Assay kit makes it possible to determine phenylalanine, tyrosine and tryptophan in an easy, fast and precise method. The Phenylalanine, Tyrosine & Tryptophan HPLC Assay kit includes all reagents for preparation and separation of the samples with exception of the columns (IC4000rp) and the controls (IC4000ko). Both can be supplied by Eagle Biosciences.  Besides the complete test kits it is possible to order all components separately.  Please request our single component price list.

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